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Tag Archives: Drug

A path toward more effective drug safety labeling

Changes to drug safety labeling by the Food and Drug Administration (FDA) provide patients and providers with the most up-to-date information about a product’s risk. However, too little is known about the impact of these changes and whether they have

Targeting old bottleneck reveals new anticancer drug strategy

The enzyme ribonucleotide reductase is a bottleneck for cancer cell growth. Scientists at Winship Cancer Institute of Emory University have identified a way of targeting ribonucleotide reductase that may avoid the toxicity of previous approaches, informing focused drug discovery efforts.

The opioid crisis: Drug overdose deaths are down for the first time in 30 years

Drug overdoses cause more deaths in the U.S. than gun violence, car accidents, or H.I.V. did when they reached their most lethal peaks. For almost three decades, the number of overdose deaths increased unabated. But, according to a recent government

Early drug intervention reduces risk of cardiovascular events in rheumatoid arthritis sufferers

People who develop rheumatoid arthritis as older adults benefit from early and sustained use of a drug called Methotrexate (MTX), a recent study led by University of Toronto researcher Jessica Widdifield has found. The study, the first of its kind

Dosing regimen for an old cancer drug shows new promise as an immunotherapy

As cancer cells progress, they accumulate hundreds and even thousands of genetic and epigenetic changes, resulting in protein expression profiles that are radically different from that of healthy cells. But despite their heavily mutated proteome, cancer cells can evade recognition

About 44% of high school seniors who misuse prescription drugs have multiple drug sources

Roughly 11% of high school seniors reported prescription drug misuse during the past year, and of those, 44% used multiple supply sources, according to a pair of University of Michigan studies. More than 70% of adolescents who obtained prescription drugs

Researchers identify possible drug target for deadly heart condition

A genetic mutation linked to dilated cardiomyopathy, a dangerous enlargement of the heart’s main pumping chamber, activates a biological pathway normally turned off in healthy adult hearts, according to a study by researchers at the Stanford University School of Medicine.

Promising system delivers chemo drug straight into tumors with fewer side effects

A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. Thinking the drugs are tasty fats, tumors invite the drug inside. Once there, the targeted drug activates, immediately suppressing tumor growth. The drug

Record drug deaths in Scotland are a national scandal

Every early death, like that of Karen McDade who died in Dundee aged 43, is a tragedy for that person and their family. Sadly, an increasing number of families in Scotland are affected by these tragedies. In 2018, 1,187 people

Heart drug could significantly increase survival rates for children with an aggressive form of brain tumour

Researchers at the University of Nottingham have discovered that repurposing a heart drug could significantly increase the survival rate for children with ependymoma—a type of brain tumor. The findings, published in Scientific Reports and led by experts in the University’s

Turbo chip for drug development

In spite of increasing demand, the number of newly developed drugs decreased continuously in the past decades. The search for new active substances, their production, characterization, and screening for biological effectiveness are very complex and costly. One of the reasons

Medicare drug rebate plan withdrawn by Trump administration

(HealthDay)—A plan to let Medicare patients receive rebates that drug companies currently pay to insurers and middlemen has been withdrawn by the Trump administration. The rebates would have been paid directly to seniors in the Medicare Part D program when

Drug-free methods to protecting kidney function

When people think of life-threatening diseases, the first thing that comes to mind is either heart disease or cancer. While both remain to be the leading causes of death in the U.S., it’s interesting to note that deaths from these

New leukemia drug is more effective and easier to use

A Wright’s stained bone marrow aspirate smear from a patient with precursor B-cell acute lymphoblastic leukemia. Credit: VashiDonsk/Wikipedia A landmark study co-authored by a Loyola Medicine oncologist has found that a newer targeted drug is significantly more effective than standard

Drug overdose death rate increasing among middle-aged women

(HealthDay)—From 1999 to 2017, the drug overdose death rate increased 260 percent among women aged 30 to 64 years, according to research published in the Jan. 11 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality